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Omicron today

The latest from Johns Hopkins:

OMICRON EARLY DATA As scientists worldwide continue to learn more about the newly identified SARS-CoV-2 variant of concern (VOC) Omicron (B.1.1.529), early data from South Africa suggest that the VOC could be more transmissible and more likely to evade existing immunity from vaccination or natural infection but may cause less serious illness than previous variants. However, experts cautioned about placing too much emphasis on these early indications because of Omicron’s novel nature and information on hospitalizations and deaths typically lag several weeks behind initial outbreaks. In South Africa, where some of the earliest Omicron cases were detected, the variant is spreading at an alarming pace, with a near vertical spike in the number of new COVID-19 cases. One estimate, which is not yet peer-reviewed, shows a doubling time of about 3.3 days, more than twice as quickly as Delta. A preprint report on Omicron’s clinical presentations at a large hospital in South Africa suggests the variant may cause less severe disease, although it is still too early to draw conclusions. 

There are concerns that Omicron could be more transmissible due to its large number of spike protein mutations, some of which have not been seen in other variants. One preprint analysis (not yet peer-reviewed) conducted by the US-based research firm nference speculates Omicron could have acquired a specific insertion mutation (ins214EPE) from the genome of a different virus, such as a seasonal coronavirus that causes the common cold. The researchers said this genetic code, which has not been detected in other SARS-CoV-2 variants, could make the virus more likely to evade some immune system responses and make it more accustomed to human hosts.

Another preprint study (not yet peer-reviewed) from South Africa suggests Omicron may carry an increased risk of reinfection, indicating the virus could escape some immune system defenses and raising questions about vaccine-induced immunity. Previous infection offered some protection against the Beta and Delta variants, but reinfections have increased since the emergence of Omicron. Additional research is needed into Omicron’s potential for immune escape, and experts note that existing immunity—whether from previous infection or vaccination—could still provide some protection from severe disease, hospitalization, or death.

So, basically, wait and see and in the meantime do everything you can to protect yourself:

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